Evaluation ofd-amphetamine effects on the binding of dopamine D-2 receptor radioligand,18F-fallypride in nonhuman primates using positron emission tomography

Synapse ◽  
1997 ◽  
Vol 27 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Jogeshwar Mukherjee ◽  
Zhi-Ying Yang ◽  
Robert Lew ◽  
Terry Brown ◽  
Shara Kronmal ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Nonhuman Primates ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primates

NeuroImage ◽  
2012 ◽  
Vol 63 (1) ◽  
pp. 232-239 ◽  
Author(s):  
Jonas Hannestad ◽  
Jean-Dominique Gallezot ◽  
Thomas Schafbauer ◽  
Keunpoong Lim ◽  
Tracy Kloczynski ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Systemic Inflammation ◽  
Nonhuman Primates ◽  
Emission Tomography ◽  
Positron Emission

In Vivo High Intrinsic Efficacy of Triazolam: A Positron Emission Tomography Study in Nonhuman Primates

2008 ◽  
Vol 62 (3) ◽  
pp. 1102-1111 ◽  
Author(s):  
Michel Bottlaender ◽  
Emmanuel Brouillet ◽  
Marina Varastet ◽  
Christine Breton ◽  
Lorenz Schmid ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Nonhuman Primates ◽  
Emission Tomography ◽  
Positron Emission Tomography Study ◽  
Intrinsic Efficacy ◽  
Positron Emission

Positron emission tomography with 18F-DOPA: Interpretation and biological correlates in nonhuman primates

1992 ◽  
Vol 45 (3) ◽  
pp. 153-168 ◽  
Author(s):  
Doris J. Doudet ◽  
Thomas G. Aigner ◽  
Catherine A. McLellan ◽  
Robert M. Cohen
Keyword(s):  
Positron Emission Tomography ◽  
Nonhuman Primates ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals A New Positron Emission Tomography Probe for Orexin Receptors Neuroimaging

Molecules ◽  
2020 ◽  
Vol 25 (5) ◽  
pp. 1018 ◽  
Author(s):  
Ping Bai ◽  
Sha Bai ◽  
Michael S. Placzek ◽  
Xiaoxia Lu ◽  
Stephanie A. Fiedler ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Pet Imaging ◽  
Nonhuman Primates ◽  
Therapeutic Potential ◽  
Emission Tomography ◽  
Orexin Receptors ◽  
Positron Emission ◽  
The Brain ◽  
Brain Positron Emission Tomography

The orexin receptor (OX) is critically involved in motivation and sleep−wake regulation and holds promising therapeutic potential in various mood disorders. To further investigate the role of orexin receptors (OXRs) in the living human brain and to evaluate the treatment potential of orexin-targeting therapeutics, we herein report a novel PET probe ([11C]CW24) for OXRs in the brain. CW24 has moderate binding affinity for OXRs (IC50 = 0.253 μM and 1.406 μM for OX1R and OX2R, respectively) and shows good selectivity to OXRs over 40 other central nervous system (CNS) targets. [11C]CW24 has high brain uptake in rodents and nonhuman primates, suitable metabolic stability, and appropriate distribution and pharmacokinetics for brain positron emission tomography (PET) imaging. [11C]CW24 warrants further evaluation as a PET imaging probe of OXRs in the brain.

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